Thymectomized Mice Thymus Grafts in Neonatally Tolerance Induction with
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Studies on the Role of the Thymus in Immunobiology
The immunologic competence of spleen cells of mice, as assessed by their graft versus host capabilities, increases to 35 days of age and beyond. Thymectomy at any point along this continuum of development produces "immunologic arrest;" the peripheral lymphoid tissues of such mice do not show significant increases in activity as the animals mature, nor is there appreciable loss of activity up to...
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Neonatally thymectomized mice were implanted with thymus grafts composed of epithelial reticular cells for periods of 7 and 14 days. Regardless of whether the grafts were placed immediately after thymectomy, or at 3 wk of age, there was little recovery of the lymphocyte depletion and impaired immunologic responsiveness, characteristically found in a neonatally thymectomized host. The findings w...
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A progressive decrease of the restoring effectivity of syngeneic or allogeneic thymus and functional thymoma grafts was observed when the treatment of neonatally thymectomized mice was delayed. Early treatment (5-20 days postthymectomy) was effective, while the number of restored animals was markedly decreased after late treatment (30-50 days postthymectomy). Similar results were obtained with ...
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Long-lived, immunologically vigorous (C3H(f) x A(f))F(1) hybrids were produced after lethal irradiation by administration of spleen cells from C3H(f) or syngeneic donors. Further, neonatally thymectomized C3H(f) or A(f) strain donors reconstituted irradiated C3H(f) or (C3H(f) x A(f))F(1) hosts. In addition, C3H(f) spleen cells from nonthymectomized 10- to 15-day-old donors protected irradiated ...
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1. Immunologic function, growth, and longevity of neonatally thymectomized mice was restored by intraperitoneal administration of 100 to 400 million syngeneic, hemiallogeneic, or ailogeneic thymus cells from newborn or adult donors. Assays of the graft versus host capabilities of spleen cells from the animals restored with allogeneic cells showed that their immunologically competent cells are o...
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